AASLD, ACG, the AGA Institute and ASGE have released the “Position statement: nonanesthesiologist administration of propofol for GI endoscopy,” which concludes that the administration by nonanesthesiologists of propofol versus sedation with commonly used agents is comparable with respect to their efficacy and safety profiles. Proper training and patient selection are crucial for the safe practice of nonanesthesiologist-administered propofol (NAAP) sedation.
The Sedation Task Force, which was chaired by Lawrence B. Cohen, MD, and included representatives from each of the four societies, was convened to develop a document designed to provide an evidence-based assessment of propofol-mediated sedation by properly trained gastroenterologists and other nonanesthesiologists. The document was reviewed and approved by the governing boards of all four societies.
A number of recommendations are made in the statement regarding NAAP for GI endoscopy:
Safety of NAAP equivalent to “standard” sedation: The safety profile of NAAP is equivalent to that of “standard” sedation with commonly used agents such as a narcotic and a benzodiazepine with respect to the risks of hypoxemia, hypotension, and bradycardia for upper endoscopy and colonoscopy. The safety profile of NAAP when it is administered during endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) appears to be equivalent to that of standard sedation. The worldwide experience with NAAP during these procedures (EUS and ERCP), however, is insufficient to draw definitive conclusions about its use in these settings.
Efficacy of NAAP for GI endoscopy: For upper endoscopy, colonoscopy, ERCP, and EUS, the time for sedation induction is shorter with NAAP than with sedation with commonly used agents. Recovery time for upper endoscopy, colonoscopy, ERCP, and EUS when using NAAP is shorter than for sedation with a narcotic and a benzodiazepine. Patient satisfaction with NAAP is equivalent or slightly superior to that with standard sedation.
Economics of NAAP for GI endoscopy: For ERCP and EUS, NAAP is more cost-effective than standard sedation. Nonanesthesiologist-administered propofol sedation improves practice efficiency when compared to sedation with commonly used agents. The use of anesthesiologist-administered sedation for healthy, low-risk patients undergoing routine GI endoscopy results in higher costs with no proven benefit with respect to patient safety or procedural efficacy.
Training guidelines for NAAP for GI endoscopy:
Ø NAAP requires the acquisition of skills and abilities that are distinct and apart from those necessary for standard sedation. Training programs should provide both didactic and practical, hands-on learning experiences.
Ø Individuals administering propofol should be proficient in the management of upper and lower airway complications, including manual techniques for re-establishing airway patency, use of oral and nasal airway devices, and proper bag-mask ventilation. Basic life support or advanced cardiac life support certification is required. Training with life-size manikins and/or human simulators improves the acquisition of these skills.
Ø Preceptorship (practical experience and training that is supervised by an expert such as an anesthesiologist or qualified endoscopist) is an important element of training for physicians and nursing personnel acquiring the skills to administer propofol.
Ø Capnography (a monitoring device that measures the concentration of carbon dioxide in exhaled air and displays a numerical readout and waveform tracing) reduces the occurrence of apnea and hypoxemia during ERCP/EUS and upper endoscopy/colonoscopy.
Read the statement published in the December issues of Hepatology, the American Journal of Gastroenterology, Gastroenterology and GIE: Gastrointestinal Endoscopy.